David W Hein Selected Research

N-acetyltransferase 1

1/2022	Deletion of arylamine N-acetyltransferase 1 in MDA-MB-231 human breast cancer cells reduces primary and secondary tumor growth in vivo with no significant effects on metastasis.
1/2022	560G>A (rs4986782) (R187Q) Single Nucleotide Polymorphism in Arylamine N-Acetyltransferase 1 Increases Affinity for the Aromatic Amine Carcinogens 4-Aminobiphenyl and N-Hydroxy-4-Aminobiphenyl: Implications for Cancer Risk Assessment.
1/2022	Identification and characterization of potent, selective, and efficacious inhibitors of human arylamine N-acetyltransferase 1.
1/2022	Arylamine N-Acetyltransferase 1 Activity is Regulated by the Protein Acetylation Status.
1/2021	Human Arylamine N-Acetyltransferase 1 (NAT1) Knockout in MDA-MB-231 Breast Cancer Cell Lines Leads to Transcription of NAT2.
1/2020	CRISPR/Cas9 knockout of human arylamine N-acetyltransferase 1 in MDA-MB-231 breast cancer cells suggests a role in cellular metabolism.
1/2019	N-Acetyltransferase 1 Knockout Elevates Acetyl Coenzyme A Levels and Reduces Anchorage-Independent Growth in Human Breast Cancer Cell Lines.
11/2018	Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity.
1/2018	Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231.
1/2018	High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5α-androstane-3β,17β-Diol, or Dihydrotestosterone in Breast Cancer Cells.

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David W Hein Research Topics

Disease

44	Neoplasms (Cancer) 01/2022 - 01/2002
19	Breast Neoplasms (Breast Cancer) 01/2022 - 07/2003
9	Urinary Bladder Neoplasms (Bladder Cancer) 01/2021 - 09/2002
6	Carcinogenesis 01/2020 - 09/2002
6	Prostatic Neoplasms (Prostate Cancer) 01/2015 - 01/2002
6	Colorectal Neoplasms (Colorectal Cancer) 04/2013 - 09/2006
4	Adenoma (Adenomas) 04/2013 - 03/2002
4	Non-Hodgkin Lymphoma (Lymphosarcoma) 01/2013 - 08/2006
4	Inflammation (Inflammations) 06/2009 - 12/2003
3	Neoplasm Metastasis (Metastasis) 01/2022 - 01/2019
3	Polyps 04/2013 - 02/2008
3	Genetic Predisposition to Disease (Genetic Predisposition) 02/2011 - 04/2004
3	Congenital Abnormalities (Deformity) 02/2011 - 09/2007
3	Pancreatic Neoplasms (Pancreatic Cancer) 06/2008 - 01/2006
3	Adenocarcinoma 06/2008 - 07/2004
2	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 01/2022 - 07/2007
2	Hepatocellular Carcinoma (Hepatoma) 06/2015 - 07/2006
2	Lymphoma (Lymphomas) 01/2013 - 12/2008
2	Stomach Neoplasms (Stomach Cancer) 07/2009 - 03/2005
2	Cardiomyopathies (Cardiomyopathy) 06/2009 - 08/2008
2	Diabetic Cardiomyopathies 06/2009 - 08/2008
2	Colonic Neoplasms (Colon Cancer) 02/2008 - 09/2002
2	Drug-Related Side Effects and Adverse Reactions 05/2007 - 01/2005
2	Necrosis 01/2006 - 12/2003
2	Hepatitis 01/2006 - 12/2003
1	Tuberculosis (Tuberculoses) 01/2021
1	Insulin Resistance 01/2020
1	Dyslipidemias (Dyslipidemia) 01/2020
1	Type 2 Diabetes Mellitus (MODY) 10/2018
1	Essential Hypertension 12/2017
1	Bacterial Pneumonia 06/2017
1	Genetic Risk Score 04/2013
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 01/2013
1	Mitochondrial Diseases (Mitochondrial Disease) 03/2012
1	Progressive Supranuclear Palsy (Steele Richardson Olszewski Syndrome) 03/2012

Drug/Important Bio-Agent (IBA)

31	CarcinogensIBA 01/2022 - 01/2002
29	N-acetyltransferase 1IBA 01/2022 - 01/2002
27	AcetyltransferasesIBA 01/2020 - 01/2002
16	AminesIBA 01/2022 - 01/2002
13	EnzymesIBA 01/2022 - 01/2006
12	Pharmaceutical PreparationsIBA 01/2022 - 04/2004
7	SmokeIBA 01/2021 - 07/2003
6	Estrogen ReceptorsIBA 01/2022 - 06/2015
5	N-acetyltalosaminuronic acid (NAT)IBA 05/2012 - 08/2005
5	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 06/2008 - 03/2002
4	4-biphenylamineIBA 01/2022 - 02/2018
4	DNA (Deoxyribonucleic Acid)IBA 01/2020 - 03/2005
4	Arylamine N-AcetyltransferaseIBA 01/2017 - 07/2008
4	MutagensIBA 11/2012 - 08/2006
4	Hair DyesIBA 12/2011 - 03/2003
4	QuinoxalinesIBA 11/2009 - 03/2002
4	CytochromesIBA 06/2008 - 03/2003
3	Messenger RNA (mRNA)IBA 08/2018 - 07/2006
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2015 - 12/2003
3	Glutathione Transferase (Glutathione S-Transferase)IBA 12/2011 - 07/2003
3	Superoxide DismutaseIBA 10/2010 - 03/2005
3	DNA AdductsIBA 11/2009 - 07/2007
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2009 - 09/2004
2	Biological ProductsIBA 01/2021 - 02/2011
2	RNA (Ribonucleic Acid)IBA 01/2021 - 08/2018
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 06/2009
2	LipidsIBA 01/2020 - 06/2009
2	Small Interfering RNA (siRNA)IBA 01/2020 - 01/2018
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 09/2004
2	Genetic Markers (Genetic Marker)IBA 01/2015 - 04/2012
2	AntioxidantsIBA 01/2015 - 08/2008
2	XenobioticsIBA 02/2011 - 09/2007
2	benzocycloheptapyridineIBA 11/2009 - 09/2006
2	MetallothioneinIBA 06/2009 - 08/2008
2	Alanine Transaminase (SGPT)IBA 01/2006 - 09/2004
1	theasinensin AIBA 01/2022
1	sirtinolIBA 01/2022
1	alizarinIBA 01/2022
1	Histone Deacetylase InhibitorsIBA 01/2022
1	SirtuinsIBA 01/2022
1	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 01/2022
1	Isoniazid (Ftivazide)FDA LinkGeneric 01/2021
1	Triglycerides (Triacylglycerol)IBA 01/2020
1	oxidized low density lipoproteinIBA 01/2020
1	2-aminofluoreneIBA 01/2020
1	Acetyl Coenzyme A (Acetyl-CoA)IBA 01/2019
1	AgarIBA 01/2019
1	Estrogens (Estrogen)FDA Link 08/2018
1	Estradiol (Delestrogen)FDA LinkGeneric 01/2018
1	Perilipin-1IBA 01/2018
1	Dithiothreitol (Cleland's Reagent)IBA 01/2018
1	Phenobarbital (Luminal)FDA Link 01/2018
1	Dihydrotestosterone (Androstanolone)IBA 01/2018
1	Hydralazine (Apresoline)FDA LinkGeneric 12/2017
1	Anti-Bacterial Agents (Antibiotics)IBA 06/2017
1	MacrolidesIBA 06/2017
1	solithromycinIBA 06/2017
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 01/2017
1	9,10-Dimethyl-1,2-benzanthraceneIBA 01/2017
1	Dehydroepiandrosterone (DHEA)IBA 06/2015
1	GTP-Binding Proteins (G-Protein)IBA 06/2015
1	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 03/2012
1	Coloring Agents (Dyes)IBA 12/2011

Therapy/Procedure

2	Therapeutics 01/2021 - 12/2017
2	Chemoprevention 02/2008 - 04/2004